Pharmacodynamics enrofloxacin mushonga wakafara spectrum bactericidal kumhuka fluoroquinolone. Iine mhedzisiro yakanaka pa escherichia coli, salmonella, klebsiella, brucella, pasteurella, actinobacillus pleuropneumoniae, erysipelas, proteus, serratia marcescens, corynebacterium pyogenes, portococcus septicus, staphylococcus aureus, It chlamydia, mycoplasma, etc. aeruginosa uye streptococcus, uye kushaya simba pane anaerobic mabhakitiriya. Iyo ine pachena post-antibacterial mhedzisiro pahutachiona hwehutachiona. Iyo antibacterial mashandiro echigadzirwa ichi ndeye inhibit bhakitiriya dna kutenderera enzyme, kukanganisa bhakitiriya dna kudzokororwa, kunyora uye kugadzirisa kudzokororwa, mabhakitiriya haagone kukura uye kubereka zvakajairwa uye kufa.
Pharmacokinetics iyo intramuscular absorption yechigadzirwa ichi inokurumidza uye yakakwana, ine bioavailability ye91.9% munguruve uye 82% mumombe dzemukaka. Inoparadzirwa zvakanyanya mumhuka uye inogona kupinda munyama uye mvura yemuviri zvakanaka, kunze kwecerebrospinal fluid, kuwanda kwemishonga munenge matushu ese akakwirira kupfuura ari muplasma. Chiropa chemetabolism chinonyanya kugadzira ciprofloxacin nekubvisa ethyl ye7-piperazine ring, inoteverwa neoxidation uye glucuronic acid inosunga. Inonyanya kubudiswa neitsvo (ne renal tubule secretion uye glomerular filtration), uye 15% kusvika ku50% inobudiswa kubva muweti muchimiro chayo chepakutanga. Iyo yekubvisa hafu yehupenyu inosiyana zvakanyanya mumhando dzakasiyana uye nzira dzakasiyana dzekutonga. Kubvisa hafu yeupenyu mushure mejojo muscular is 5.9 maawa mumhou, 9.9 maawa mumabhiza, 1.5 kusvika 4.5 maawa mumakwai, uye 4.6 maawa munguruve.
1. Ichi chigadzirwa chine synergistic effect kana chikashandiswa neaminoglycoside kana broad-spectrum penicillin.
2. Heavy metal ions yakadai se ca2 +, mg2+, fe3+ uye al3+ canchelate nechigadzirwa ichi uye inokanganisa kutora.
3. Kana yakabatanidzwa ne theophylline uye caffeine, inogona kuderedza kusungirirwa kweprotein yeplasma, kuwedzera kusingawanzoitiki kweiyo theophylline uye caffeine muropa, uye kunyange kuonekwa zviratidzo zveophylline chepfu.
4. Ichi chigadzirwa chine simba rekudzivirira chiropa chemishonga enzymes, iyo inogona kuderedza chiyero chekuregererwa kwemishonga inonyanya kushandiswa muchiropa uye kuwedzera kuwedzerwa kwemishonga yeropa.
Fluoroquinolone antibacterial mishonga. Inoshandiswa kune zvipfuwo uye huku zvirwere zvebhakitiriya uye mycoplasma utachiona.
Intramuscular jekiseni: Chiyero chimwe chete, 0.025ml pa1kg yehuremu hwemombe, hwai nenguruve; 0.025 ~ 0.05ml yembwa, katsi uye tsuro. Shandisa 1 kusvika 2 kanomwe pazuva kwemazuva maviri kusvika matatu.
1. Cartilage degeneration mumhuka duku, kukanganisa kukura kwemapfupa uye kukonzera kukamhina uye kurwadziwa.
2. Maitiro ekugadzirisa kudya kunosanganisira kurutsa, kurasikirwa kwechido, manyoka uye nokukurumidza.
3. Kuita kweganda kunosanganisira erythema, pruritus, urticaria uye photosensitivity.
4. Allergic reactions, ataxia, kugumburwa kunoonekwa mumbwa nemakati.
1. Iine simba rinokwanisa kufadza pa central system, inokonzera pfari, uye inofanira kushandiswa nekuchenjerera mumbwa dzepfari.
2. Mhuka dzinodya nyama nemhuka dzine urombo hweitsvo dzinofanira kushandiswa nokungwarira, izvo zvinogona kupota zvichikonzera crystalline weti.
3. Ichi chigadzirwa hachina kukodzera mabhiza. Majekiseni eIntramuscular anoshatisa kwenguva pfupi.
4. Ichi chigadzirwa hachifaniri kushandiswa imbwa pamberi pemavhiki masere ezera.
5. Mishonga inopesana nemishonga yechigadzirwa ichi iri kuwedzera uye haifaniri kushandiswa mu subtherapeutic doses kwenguva yakareba.
