Pharmacodynamics flufenicol is wide spectrum antibiotic.
Yemaaminools, bacteriosuppressor, uye inoshanda nekusunga neiyo ribosome 50s subunit kuvharira kuumbwa kwemapuroteni ebhakitiriya. Iine simba rinorwisa mabhakitiriya rinopikisa zvakasiyana-siyana zve gram-positive uye gram-negative mabhakitiriya. Pasteurella hemolyticus, pasteurella multocida uye actinobacillus suis pleuropneumoniae vainzwa zvakanyanya neflufenicol. In vitro, basa reantimicrobial reflufenicol kurwisa tupukanana twakawanda rakafanana kana kuti rakasimba kupfuura re sulfenicol, uye mamwe mabhakitiriya anopokana neaminools nekuda kweacetylation, senge escherichia coli uye klebsiella pneumoniae, anogona kunge achiri kunzwa kune flufenicol.
Inonyanya kushandiswa kune zvirwere zvebhakitiriya zvenguruve, huku nehove zvinokonzerwa nebhakitiriya inonzwisisika, zvakadai sezvirwere zvekufema zvemombe nenguruve zvinokonzerwa ne pasteurella hemolyticus, pasteurella multocida uye actinobacillus pleuropneumoniae. Typhoid uye paratyphoid inokonzerwa nesalmonella, huku cholera, huku chena dysentery, colibacillosis, nezvimwewo; hove pasteurella, vibrio, staphylococcus aureus, hydroomonas, enteritis uye mamwe mabhakitiriya anokonzerwa nehove bhakitiriya septicemia, enteritis, erythroderma uye nokukurumidza.
Pharmacokinetics flufenicol inokurumidza kubatwa nekutonga kwemukati, uye kurapa kwehutano kunogona kusvika muropa mushure meawa imwe, uye huwandu hwepamusoro hweropa hunogona kusvika mumaawa 1 kusvika ku3. Iyo bioavailability inopfuura 80%. Flufenicol inoparadzirwa zvakanyanya mumhuka uye inogona kuyambuka ropa-brain barriers. Inobudiswa kunyanya muweti muchimiro chayo chepakutanga uye mune zviduku zvishoma mumarara.
1. Macrolides uye lincoamines vane chinangwa chakafanana nechigadzirwa ichi, ivo vanosanganiswa nebhakitiriya ribosome 50s subunit, uye inogona kuunza migumisiro inopikisa kana yakabatanidzwa.
2. Inogona kupikisa basa rebhakitiriya repenicillin kana aminoglycosides, asi harina kuratidzwa mumhuka.
Amidoalcohol antibiotics, inonyanya kunzwisiswa nePasteurella hemolyticus, Pasteurella multocida uye actinobacillus pleuropneumoniae, inoshandiswa paPasteurella neEscherichia coli zvirwere.
Intramuscular jekiseni: imwe dose, pa1kg uremu hwemuviri, 0.2ml yehuku, 0.15 ~ 0.2ml yemakwai nenguruve, 0.075 ~ 0.1ml yemabhiza nemombe. Kamwe pamaawa makumi mana nemasere, kaviri mukutevedzana. Hove 0.005 kusvika 0.01ml kamwe pazuva.
1. Ichi chigadzirwa chine imwe immunosuppressive effect kana yakashandiswa yakakwirira kudarika inokurudzirwa dose.
2. Iine fetal toxicity, uye inofanira kushandiswa nekuchenjerera panguva yekuzvitakura nekuyamwisa zvipfuwo.
1. nguva yekukandira huku inorambidzwa.
2. mhuka dzine simba rekudzivirira zvirwere kana nguva yekudzivirira inofanira kurambidzwa.
3. mhuka dzine renal insufficiency dzinofanira kuderedzwa zvakanaka kana kuwedzerwa nguva yekutonga nguva.
