10% Iron Dextran Jekiseni

Pharmacodynamic iron ndiyo chikamu chikuru che hemoglobin uye myoglobin. Hemoglobin ndiyo inotakura oxygen mumasero matsvuku eropa. Myoglobin ndiko uko masero emhasuru anochengeta okisijeni kuti ibatsire kuipa kumamhasuru panguva yekurovedza muviri. Mazhinji ema enzymes uye zvinhu zvinobatanidzwa mukutenderera kwe tricarboxylic acid zvine iron kana kushanda chete pamberi pesimbi. Naizvozvo, pamusoro pekukasira hemoglobin synthesis, zviratidzo zvine chekuita nekushomeka kwesimbi uye kuderera kwekuita kwema enzymes ane iron, sekunonoka kukura, kusakwana kwehunhu, uye kushomeka kwemuviri, zvinogona kugadziriswa zvishoma nezvishoma mushure mekushanda kwesimbi kuwedzera mumhuka dzisina iron. Pharmacokinetic iron yejekiseni inotorwa nekukurumidza kupfuura yemuromo iron; mushure me intramuscular jekiseni re iron dextran, huwandu hweropa hwakasvika pakakwirira pamaawa 24-48, uye molecule yayo yakanga yakakura. Yakabatwa nemidziyo ye lymphatic ndokubva yaendeswa muropa, uye kuwedzera kweropa kwakawedzera zvishoma nezvishoma; mushure mekupinda mutsinga kana intramuscular jekiseni mukutenderera kweropa, iri phagocytic uye yakaora kuita iron uye dextran ne mononuclear phagocytic cell system. Mushure mekutora, iyoni yesimbi inoiswa oxidized kune ferric ions ne ceruloplasmin muropa, uye zvino inosunga kune transferrin receptors, inopinda mumasero muchimiro chepinocytosis yemasero eropa, kana kuunganidza muchimiro cheferritin kana hemosiderin muchiropa, spleen, bone marrow uye mamwe mononuclear cell system phago. Mapuroteni anosunga mwero akakwira muhemoglobin, asi yakaderera mumyoglobin, ma enzymes uye iron-inotakura mapuroteni, pamwe nekuderera mu ferritin kana hemosiderin.