Pharmacodynamic lincomycin ndeye lincoamine antibiotics, i bacteriostatic agent, mabhakitiriya ane ngozi anosanganisira staphylococcus aureus (kusanganisira penicillin-resistant strains), streptococcus, pneumococcus, bacillus anthracis, erysipelas suis, mamwe mycoplasma (mycoplasma plasma, mycoplasma, mycoplasma, mycoplasma synovialis), leptospirosis uye anaerobic mabhakitiriya (akadai se clostridium difficile, clostridium tetanus, clostridium percapsulatus uye yakawanda actinomyces). Inonyanya kushanda pa50s subunit yebhakitiriya ribosome, uye inoshandisa antibacterial effect nekudzivisa kuwedzera kweketani yepeptide uye kukanganisa protein synthesis.
Kutora kwakakurumidza mushure mejojo ye intramuscular, ine jekiseni rimwe chete remumuscular re 11mg / kg munguruve uye nhamba yepamusoro yeropa ye6.25μg / ml. Iyo plasma protein inosunga mwero yaive 57% - 72%. Iyo inoparadzirwa zvakanyanya mu vivo, ine vhoriyamu inooneka yekugovera ye2.8 l / kg munguruve. Inoparadzirwa zvakanyanya mumvura dzakasiyana-siyana dzemuviri uye matishu (kusanganisira bhonzo), pakati peiyo kuwanda kwechiropa neitsvo ndiko kwakanyanya, uye kuwanda kwemushonga wematishu kwakapetwa kakati wandei kupfuura iyo serum panguva imwe chete. Inogona kupinda mu placenta, asi hazvisi nyore kupinda muropa-brain chipingamupinyi, uye zvakaoma kusvika kuhutano hunobudirira hwemishonga mu cerebrospinal fluid kana kuzvimba kuchiitika. Inogona kugoverwa kumukaka, uye kuiswa mumukaka kwakafanana neiyo muplasma. Chikamu chemushonga chinogadziriswa muchiropa, uye fomu yemishonga uye metabolites yayo inobudiswa kuburikidza ne bile, weti uye mukaka. Excretion in stool inogona kunonoka kwemazuva akati wandei, saka ine inhibitory mhedzisiro pane intestinal sensitive microorganisms.
1. Kana yakabatanidzwa nejentamicin, ine synergistic effect pa gram-positive mabhakitiriya akadai se staphylococcus uye streptococcus.
2. Kana yasanganiswa neaminoglycosides uye polypeptide antibiotics, inogona kuwedzera kuvharira kwekuita pane neuromuscular junction. Yakasanganiswa ne erythromycin ine antagonistic effect, nokuti nzvimbo yechiitiko yakafanana, uye erythromycin ine hukama hwakasimba kune 50s subunit yebhakitiriya ribosomes pane chigadzirwa ichi.
3. Haifaniri kusanganiswa nemishonga inorwisa manyoka inodzivisa intestinal peristalsis uye ine ivhu jena. 4. Pane kusawirirana nekanamycin, neomycin, nezvimwewo.
Lincoamine antibiotics. Kune giramu-positive bhakitiriya utachiona, inogonawo kushandiswa kune treponemosis uye mycoplasma nezvimwe zvirwere.
Intramuscular jekiseni: Mumwe muyero, 0.0165 ~ 0.033ml pa 1kg uremu muviri mabhiza nemombe, 0.033ml hwai nenguruve, kamwe pazuva; 0.033ml yembwa nekatsi, kaviri pazuva, kwemazuva matatu kusvika mashanu.
Intramuscular injection inogona kukonzera manyoka kwenguva pfupi kana tsvina yakapfava. Kunyange zvazvo zvisingawanzoitiki, matanho anodiwa anofanira kutorwa kudzivirira kupera mvura mumuviri kana zvikaitika.
