Pharmacodynamic damamycin ndeye aminoglycoside mishonga inorwisa mabhakitiriya, uye ine mwero inhibitory mhedzisiro pamhando dzakasiyana dze gram-negative bacilli, senge escherichia coli, salmonella, shigella, proteus uye zvichingodaro. Inonzwa kune streptococcus, pneumococcus, staphylococcus epidermidis uye mamwe mycoplasma (yakadai se mycoplasma gallinarum, mycoplasma turkey, mycoplasma synovialis, nezvimwewo). Inonyanya kusava nehanya kune streptococcus viridis uye staphylococcus aureus. Kazhinji inopikisa pseudomonas aeruginosa uye treponemas. Mabhakitiriya emudumbu anoshingirira zvakanyanya kumegamycin, asi haaratidzi kuchinjika ne streptomycin. Lincomycin ine yakanaka antibacterial kuita kurwisa anaerobic mabhakitiriya, akadai se clostridium, peptococcus, peptostreptococcus, clostridium tetanus, clostridium perfringens uye akawanda actinomyces. Lincomycin inonyanya kushanda pa50s subunit yebhakitiriya ribosomes, iyo inokanganisa mapuroteni synthesis nekudzivisa kuwedzera kwepeptide chain.
Pharmacokinetics chete 7% yelincomycin inobatwa mushure mekutonga kwemukati, asi inochengetedza huwandu hwepamusoro muhutano hwemimba. Mushonga wematishu wemushonga wakaderera pane weserum concentration. Hazvisi nyore kupinda mu cerebrospinal fluid kana ziso, uye kusungirirwa kweprotein ye plasma haisi yakakwirira. Mishonga yakawanda inobudiswa ne glomerular filtration mune yavo yepakutanga fomu. Iyo bioavailability yelincomycin ndeye 30% ~ 40% nekusabatwa zvakanaka mukutonga nemuromo. Huwandu hwekunwa uye huwandu hwelincomycin hunogona kudzikiswa nekudya kwakasanganiswa. Huku dzakapihwa 50mg yechigadzirwa ichi (yakanyungudika mumvura yekunwa) pakg yehuremu hwemuviri kwemazuva manomwe. Munguva yekuedzwa, plasma lincomycin yakasvika 0.14 μ g/ml, nepo daguanmycin yaive yakanyanya kudiki. Mushure memazuva manomwe ekuyedzwa, yakapfuura 0.1μg/ml.
1. Yakasanganiswa nelincomycin, inogona kuwedzera zvakanyanya basa reantibacterial kurwisa mycoplasma uye kuwedzera antibacterial spectrum.
2. Kusanganiswa kwelincomycin uye anticholinesterase mishonga inogona kuderedza kushanda kwekupedzisira.
3. Yakasanganiswa ne erythromycin ine antagonistic effect.
Mishonga inorwisa mabhakitiriya. Kune Gram-negative bacteria, Gram-positive bacteria uye mycoplasma utachiona.
Zvinwiwa zvakasanganiswa: 100g yechigadzirwa ichi yakasanganiswa nemvura 200 ~ 300kg yenguruve uye 50 ~ 100kg yehuku kwemazuva 3 ~ 5. Kudya kwakasanganiswa: 100g yekudya yakasanganiswa 100kg yenguruve uye 50kg yehuku, inoshandiswa kwemazuva mashanu kusvika manomwe.
Dyara hutano hwehutano: Kubva pamazuva manomwe asati aberekwa kusvika kumazuva manomwe mushure mekusununguka, 100g yechigadzirwa ichi inosanganiswa 100kg, kana 200kg nemvura. Kuchengeta utano hwenguruve: Isati yarumurwa uye yapedza kurumurwa uye panhanho yekuyamwisa, 100g sanganisa 100kg, kana 200kg mvura.
Hapana maitiro akashata akacherechedzwa kana akashandiswa zvinoenderana neyakatemerwa kushandiswa uye dosage.
